Evaluation of the antibacterial activity of selected Pakistani honeys against multi-drug resistant Salmonella typhi
Identifieur interne : 000653 ( Main/Exploration ); précédent : 000652; suivant : 000654Evaluation of the antibacterial activity of selected Pakistani honeys against multi-drug resistant Salmonella typhi
Auteurs : Muhammad Barkaat Hussain [Arabie saoudite] ; Abdul Hannan [Pakistan] ; Naeem Akhtar [Pakistan] ; Ghulam Qadir Fayyaz [Pakistan] ; Muhammad Imran [Arabie saoudite] ; Sidrah Saleem [Pakistan] ; Imtiaz Ahmed Qureshi [Arabie saoudite]Source :
- BMC Complementary and Alternative Medicine [ 1472-6882 ] ; 2015.
Abstract
The development of resistance to conventional anti-typhoid drugs and the recent emergence of fluoroquinolone resistance have made it very difficult and expensive to treat typhoid fever. As the therapeutic strategies become even more limited, it is imperative to investigate non-conventional modalities. In this context, honey is a potential candidate for combating antimicrobial resistance because it contains a broad repertoire of antibacterial compounds which act synergistically at multiple sites, thus making it less likely that the bacteria will become resistant. The in vitro antibacterial activity of 100 unifloral honey samples against a blood culture isolate of multi-drug resistant (MDR)
All honey samples were evaluated for both total (acidity, osmolarity, hydrogen peroxide and non-peroxide activity) and plant derived non-peroxide antibacterial activity by agar well diffusion assay at 50% and 25% dilution in sterile distilled water and 25% in catalase solution. Manuka (Unique Manuka Factor-21) honey was used for comparison. The phenol equivalence of each honey sample from 2% to 7% (w/v) phenol was obtained from regression analysis. The antibacterial potential of each honey sample was expressed as its equivalent phenol concentration. The honey samples which showed antibacterial activity equivalent to or greater than manuka honey were considered therapeutically active honeys.
Nineteen honey samples (19%) displayed higher hydrogen peroxide related antibacterial activity (16–20% phenol), which is more than that of manuka honey (21-UMF). A total of 30% of the honey samples demonstrated antibacterial activity between 11 and 15% phenol similar to that of manuka honey while 51% of the honey samples did not exhibit any zone of inhibition against MDR-
The honey samples which displayed antibacterial activity equal to or greater than manuka honey may be useful in the clinical conditions where higher hydrogen peroxide related antibacterial activity is required. Manuka honey, which is known to possess non-peroxide antibacterial activity, warrants further evaluation in a suitable typhoid animal model.
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DOI: 10.1186/s12906-015-0549-z
PubMed: 25880671
PubMed Central: 4355501
Affiliations:
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University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore, 54600 Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Akhtar, Naeem" sort="Akhtar, Naeem" uniqKey="Akhtar N" first="Naeem" last="Akhtar">Naeem Akhtar</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pathology, Rawalpindi Medical College, Rawalpindi, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pathology, Rawalpindi Medical College, Rawalpindi</wicri:regionArea><wicri:noRegion>Rawalpindi</wicri:noRegion></affiliation></author><author><name sortKey="Fayyaz, Ghulam Qadir" sort="Fayyaz, Ghulam Qadir" uniqKey="Fayyaz G" first="Ghulam Qadir" last="Fayyaz">Ghulam Qadir Fayyaz</name><affiliation wicri:level="1"><nlm:aff 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of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore, 54600 Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Qureshi, Imtiaz Ahmed" sort="Qureshi, Imtiaz Ahmed" uniqKey="Qureshi I" first="Imtiaz Ahmed" last="Qureshi">Imtiaz Ahmed Qureshi</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Pathology, Faculty of Medicine, King Abdul Aziz University, Rabigh Branch, 21589 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Pathology, Faculty of Medicine, King Abdul Aziz University, Rabigh Branch</wicri:regionArea><wicri:noRegion>Rabigh Branch</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25880671</idno><idno type="pmc">4355501</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355501</idno><idno type="RBID">PMC:4355501</idno><idno type="doi">10.1186/s12906-015-0549-z</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000558</idno><idno type="wicri:Area/Pmc/Curation">000557</idno><idno type="wicri:Area/Pmc/Checkpoint">000514</idno><idno type="wicri:Area/Ncbi/Merge">001A88</idno><idno type="wicri:Area/Ncbi/Curation">001A88</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A88</idno><idno type="wicri:Area/Main/Merge">000653</idno><idno type="wicri:Area/Main/Curation">000653</idno><idno type="wicri:Area/Main/Exploration">000653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of the antibacterial activity of selected Pakistani honeys against multi-drug resistant <italic>Salmonella typhi</italic></title><author><name sortKey="Hussain, Muhammad Barkaat" sort="Hussain, Muhammad Barkaat" uniqKey="Hussain M" first="Muhammad Barkaat" last="Hussain">Muhammad Barkaat Hussain</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Microbiology, Faculty of Medicine, King Abdul Aziz University, Rabigh Branch, 21589 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Microbiology, Faculty of Medicine, King Abdul Aziz University, Rabigh Branch</wicri:regionArea><wicri:noRegion>Rabigh Branch</wicri:noRegion></affiliation></author><author><name sortKey="Hannan, Abdul" sort="Hannan, Abdul" uniqKey="Hannan A" first="Abdul" last="Hannan">Abdul Hannan</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore, 54600 Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Akhtar, Naeem" sort="Akhtar, Naeem" uniqKey="Akhtar N" first="Naeem" last="Akhtar">Naeem Akhtar</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pathology, Rawalpindi Medical College, Rawalpindi, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pathology, Rawalpindi Medical College, Rawalpindi</wicri:regionArea><wicri:noRegion>Rawalpindi</wicri:noRegion></affiliation></author><author><name sortKey="Fayyaz, Ghulam Qadir" sort="Fayyaz, Ghulam Qadir" uniqKey="Fayyaz G" first="Ghulam Qadir" last="Fayyaz">Ghulam Qadir Fayyaz</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Plastic Surgery, Services Institute of Medical Sciences, Lahore, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Plastic Surgery, Services Institute of Medical Sciences, Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Imran, Muhammad" sort="Imran, Muhammad" uniqKey="Imran M" first="Muhammad" last="Imran">Muhammad Imran</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Faculty of Medicine, King Abdul Aziz University, Rabigh Branch, 21589 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Faculty of Medicine, King Abdul Aziz University, Rabigh Branch</wicri:regionArea><wicri:noRegion>Rabigh Branch</wicri:noRegion></affiliation></author><author><name sortKey="Saleem, Sidrah" sort="Saleem, Sidrah" uniqKey="Saleem S" first="Sidrah" last="Saleem">Sidrah Saleem</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore, 54600 Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Microbiology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Qureshi, Imtiaz Ahmed" sort="Qureshi, Imtiaz Ahmed" uniqKey="Qureshi I" first="Imtiaz Ahmed" last="Qureshi">Imtiaz Ahmed Qureshi</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Pathology, Faculty of Medicine, King Abdul Aziz University, Rabigh Branch, 21589 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Pathology, Faculty of Medicine, King Abdul Aziz University, Rabigh Branch</wicri:regionArea><wicri:noRegion>Rabigh Branch</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Complementary and Alternative Medicine</title><idno type="eISSN">1472-6882</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The development of resistance to conventional anti-typhoid drugs and the recent emergence of fluoroquinolone resistance have made it very difficult and expensive to treat typhoid fever. As the therapeutic strategies become even more limited, it is imperative to investigate non-conventional modalities. In this context, honey is a potential candidate for combating antimicrobial resistance because it contains a broad repertoire of antibacterial compounds which act synergistically at multiple sites, thus making it less likely that the bacteria will become resistant. The in vitro antibacterial activity of 100 unifloral honey samples against a blood culture isolate of multi-drug resistant (MDR) <italic>Salmonella typhi</italic> were investigated.</p></sec><sec><title>Methods</title><p>All honey samples were evaluated for both total (acidity, osmolarity, hydrogen peroxide and non-peroxide activity) and plant derived non-peroxide antibacterial activity by agar well diffusion assay at 50% and 25% dilution in sterile distilled water and 25% in catalase solution. Manuka (Unique Manuka Factor-21) honey was used for comparison. The phenol equivalence of each honey sample from 2% to 7% (w/v) phenol was obtained from regression analysis. The antibacterial potential of each honey sample was expressed as its equivalent phenol concentration. The honey samples which showed antibacterial activity equivalent to or greater than manuka honey were considered therapeutically active honeys.</p></sec><sec><title>Results</title><p>Nineteen honey samples (19%) displayed higher hydrogen peroxide related antibacterial activity (16–20% phenol), which is more than that of manuka honey (21-UMF). A total of 30% of the honey samples demonstrated antibacterial activity between 11 and 15% phenol similar to that of manuka honey while 51% of the honey samples did not exhibit any zone of inhibition against MDR-<italic>S. typhi</italic> at 50% (w/v) dilution. None of the indigenous honey samples displayed non-peroxide antibacterial activity. Only manuka honey showed non-peroxide antibacterial activity at 25% dilution (w/v) in catalase solution.</p></sec><sec><title>Conclusions</title><p>The honey samples which displayed antibacterial activity equal to or greater than manuka honey may be useful in the clinical conditions where higher hydrogen peroxide related antibacterial activity is required. Manuka honey, which is known to possess non-peroxide antibacterial activity, warrants further evaluation in a suitable typhoid animal model.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Farmakiotis, D" uniqKey="Farmakiotis D">D Farmakiotis</name></author><author><name sortKey="Varughese, J" uniqKey="Varughese J">J Varughese</name></author><author><name sortKey="Sue, P" uniqKey="Sue P">P Sue</name></author><author><name sortKey="Andrews, P" uniqKey="Andrews P">P Andrews</name></author><author><name sortKey="Brimmage, M" uniqKey="Brimmage M">M Brimmage</name></author><author><name sortKey="Dobroszycki, J" uniqKey="Dobroszycki J">J Dobroszycki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crump, Ja" uniqKey="Crump J">JA Crump</name></author><author><name sortKey="Luby, Sp" uniqKey="Luby S">SP Luby</name></author><author><name sortKey="Mintz, Ed" uniqKey="Mintz E">ED 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Sulaiman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="French, Vm" uniqKey="French V">VM French</name></author><author><name sortKey="Cooper, Ra" uniqKey="Cooper R">RA Cooper</name></author><author><name sortKey="Molan, Pc" uniqKey="Molan P">PC Molan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Al Waili, Ns" uniqKey="Al Waili N">NS Al-Waili</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Pakistan</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Hussain, Muhammad Barkaat" sort="Hussain, Muhammad Barkaat" uniqKey="Hussain M" first="Muhammad Barkaat" last="Hussain">Muhammad Barkaat Hussain</name></noRegion><name sortKey="Imran, Muhammad" sort="Imran, Muhammad" uniqKey="Imran M" first="Muhammad" last="Imran">Muhammad Imran</name><name sortKey="Qureshi, Imtiaz Ahmed" sort="Qureshi, Imtiaz Ahmed" uniqKey="Qureshi I" first="Imtiaz Ahmed" last="Qureshi">Imtiaz Ahmed Qureshi</name></country><country name="Pakistan"><noRegion><name sortKey="Hannan, Abdul" sort="Hannan, Abdul" uniqKey="Hannan A" first="Abdul" last="Hannan">Abdul Hannan</name></noRegion><name sortKey="Akhtar, Naeem" sort="Akhtar, Naeem" uniqKey="Akhtar N" first="Naeem" last="Akhtar">Naeem Akhtar</name><name sortKey="Fayyaz, Ghulam Qadir" sort="Fayyaz, Ghulam Qadir" uniqKey="Fayyaz G" first="Ghulam Qadir" last="Fayyaz">Ghulam Qadir Fayyaz</name><name sortKey="Saleem, Sidrah" sort="Saleem, Sidrah" uniqKey="Saleem S" first="Sidrah" last="Saleem">Sidrah Saleem</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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